Browsing by Author "Ferguson-Smith, A. C."
Now showing items 1-5 of 5
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Article
Balanced translocations for the analysis of imprinted regions of the mouse genome.
Ferguson-Smith, A. C.; Tevendale, M.; Georgiades, Pantelis; Grandjean, V. (2001)Experimental studies that investigate the functional and mechanistic properties of an imprinted locus require material in which the two parental chromosome homologs can be easily distinguished. The use of animals with ...
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Article
Delta-like and Gtl2 are reciprocally expressed differentially methylated linked imprinted genes on mouse chromosome 12
Takada, S.; Tevendale, M.; Baker, J.; Georgiades, Pantelis; Campbell, E.; Freeman, T.; Johnson, M. H.; Paulsen, M.; Ferguson-Smith, A. C. (2000)The distal portion of mouse chromosome 12 is imprinted. To date, however, Gtl2 is the only imprinted gene identified on chromosome 12. Gtl2 encodes multiple alternatively spliced transcripts with no apparent open reading ...
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Article
Parental origin effects in human trisomy for chromosome 14q: Implications for genomic imprinting
Georgiades, Pantelis; Chierakul, C.; Ferguson-Smith, A. C. (1998)Parental origin specific congenital anomalies have been noted in patients with uniparental disomy of the long arm of human chromosome 14 (UPD14). This suggests the presence of imprinted genes, consistent with observations ...
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Article
Parental origin-specific developmental defects in mice with uniparental disomy for chromosome 12
Georgiades, Pantelis; Watkins, M.; Surani, M. A.; Ferguson-Smith, A. C. (2000)Genetic analysis has shown that the distal portion of mouse chromosome 12 is imprinted
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Article
Roles for genomic imprinting and the zygotic genome in placental development
Georgiades, Pantelis; Watkins, M.; Burton, G. J.; Ferguson-Smith, A. C. (2001)The placenta contains several types of fetomaternal interfaces where zygote-derived cells interact with maternal cells or maternal blood for the promotion of fetal growth and viability. The genetic factors regulating the ...